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Saturday, October 12, 2013
Obama and Republicans search for a deal on U.S. fiscal impasse (Reuters)
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Tuesday, June 25, 2013
A Real-Life Iron Man Suit That Could Be as Comfortable as Pajamas
Tony Stark used exotic composites, metal alloys, and other Hollywood-only make-believe materials to build his armor-plated Iron Man suit. But researchers at Harvard University's Wyss Institute, constrained by the limitations of reality, took a different approach with a muscle-enhancing exoskeleton that could one day be as comfy to wear as your favorite pair of jeans.
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Monday, June 24, 2013
Russia defiant as U.S. raises pressure over Snowden
By Lidia Kelly and James Pomfret
MOSCOW/HONG KONG (Reuters) - Russia defied White House pressure on Monday to expel former U.S. spy agency contractor Edward Snowden to the United States before he flees Moscow on the next stop of his globe-crossing escape from U.S. prosecution.
Snowden, whose exposure of secret U.S. government surveillance raised questions about intrusion into private lives, was allowed to leave Hong Kong on Sunday after Washington asked the Chinese territory to arrest him on espionage charges.
Snowden, 29, has kept out of sight in the transit area of Moscow's Sheremetyevo airport as Ecuador says it considers his request for asylum.
His decision to fly to Russia, which like China challenges U.S. dominance of global diplomacy, is another embarrassment to President Barack Obama who has tried to "reset" ties with Moscow and build a partnership with Beijing.
The White House said it expected the Russian government to send Snowden back to the United States and lodged "strong objections" to Hong Kong and China for letting him go.
"We expect the Russian government to look at all options available to expel Mr Snowden back to the U.S. to face justice for the crimes with which he is charged," said Caitlin Hayden, spokeswoman for the National Security Council.
The Russian government ignored the appeal and President Vladimir Putin's press secretary denied any knowledge of Snowden's movements.
Asked if Snowden had spoken to the Russian authorities, Peskov said: "Overall, we have no information about him."
He declined comment on the expulsion request but other Russian officials said Moscow had no obligation to cooperate with Washington after it passed legislation to impose visa bans and asset freezes on Russians accused of violating human rights.
"Why should the United States expect restraint and understanding from Russia?" said Alexei Pushkov, the head of the foreign affairs committee in the lower house of parliament.
Putin has missed few chances to champion public figures who challenge Western governments and to portray Washington as an overzealous global policeman. But Russian leaders have not paraded Snowden before the cameras or trumpeted his arrival.
ECUADOR'S ROLE
Since leaving Hong Kong, where he feared arrest and extradition, Snowden has been searching for a country which can guarantee his security.
Ecuador said it had received an asylum request and Foreign Minister Ricardo Patino, on a trip to Vietnam, said it would be analyzed with a "lot of responsibility". He was expected to hold a news conference around 7.00 p.m. (8 a.m. EDT) in Hanoi.
A source at Russian airline Aeroflot said Snowden was booked on a flight due to depart for Havana on Monday at 2:05 p.m. (6.05 a.m. EDT). The gate for the Cuba flight was blocked and security was tightened.
A State Department official said Washington had told countries in the Western Hemisphere that Snowden "should not be allowed to proceed in any further international travel, other than is necessary to return him to the United States".
Despite the Kremlin denials, U.S. Senator Charles Schumer said Putin had probably known about and approved Snowden's flight to Russia.
"Putin always seems almost eager to stick a finger in the eye of the United States," Schumer, a senior Senate Democrat, told CNN's "State of the Union". He also saw "the hand of Beijing" in Hong Kong's decision to let Snowden leave.
But taking the higher ground after being accused of hacking computers abroad, the Chinese Foreign Ministry expressed "grave concern" over Snowden's allegations that the United States had hacked computers in China.
It said it had taken up the issue with Washington.
CHILL
Some Russians have praised Snowden's revelations. Others fear a new chill in relations with the United States.
"We are a pretty stubborn country and so is the United States. Both are mighty countries, so I would say this has a good potential to turn into a big fuss in bilateral relations," said Ina Sosna, manager of a Moscow cleaning company.
"I guess it would be best if they just let him move on from Russia to avoid any more controversy over him being here."
Snowden was aided in his escape by WikiLeaks, the anti-secrecy organization whose founder Julian Assange said he had helped to arrange documents from Ecuador.
Ecuador, like Cuba and Venezuela, is a member of the ALBA bloc, an alliance of leftist governments in Latin America that pride themselves on their "anti-imperialist" credentials. The Quito government has been sheltering Assange at its London embassy for the past year.
The New York Times quoted Assange as saying in an interview that his group had arranged for Snowden to travel on a "special refugee document" issued by Ecuador last Monday.
U.S. sources said Washington had revoked Snowden's passport. WikiLeaks said diplomats and Sarah Harrison, a British legal researcher working for the anti-secrecy group, accompanied him.
Snowden, who had worked at a U.S. National Security Agency facility in Hawaii, had been hiding in Hong Kong, a former British colony that returned to China in 1997, since leaking details about secret U.S. surveillance programs to news media.
Snowden has been charged with theft of federal government property, unauthorized communication of national defense information and willful communication of classified communications intelligence to an unauthorized person, with the latter two charges falling under the U.S. Espionage Act.
(Additional reporting by Gabriela Baczynska and Alexei Anishchuk in Moscow, Martin Petty in Hanoi, Sui-Lee Weein in Beijing,; Andrew Cawthorne, Mario Naranjo and Daniel Wallis in Caracas, Alexandra Valencia in Quito and Mark Felsenthal, Paul Eckert and Mark Hosenball in Washington; Writing by Dean Yates and Timothy Heritage, Editing by Elizabeth Piper)
Source: http://news.yahoo.com/u-warns-countries-against-snowden-travel-014740817.html
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A Wedding Dress Made Entirely Out of Lego
Japanese artist Rie Hosokai, of Daisy Balloon, created this amazing piece of high Lego fashion for Tokyo's "Piece of Peace" charity exhibit at the Parco Museum. Structurally it's simply stunning (albeit a bit Disney Princessy). The construction, contour and shape are based on Hosokai's balloon dress. As an item of haute couture, it's not so utilitarian. But as an avant-garde work-of-Lego-art it's simply stunning.
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Zhejiang Medicine To Develop Ambrx Breast Cancer Drug
Deals and Financings
Zhejiang Medicine Co. (SHA: 600216, ZHEXY.PK) formed a collaboration with Ambrx of San Diego to develop an Ambrx molecule that targets Her2-positive breast cancer (see story). Ambrx genetically engineers proteins that contain new amino acids with different properties than those of the 20 natural-occurring amino acids. In return for China rights, Zhejiang will underwrite the costs of development, which will be carried out by WuXi PharmaTech (NYSE: WX).
Suzhou Ribo Life Sciences and Life Technologies (LIFE) of California have stuck a deal giving Ribo exclusive China rights to develop and manufacture siRNA therapeutics using Life's Invivofectamine? Rx delivery technology (see story). Life Technologies will receive milestones and royalties for each drug that Ribo develops. Ribo's first product will be a treatment for hepatitis B.
Shanxi CY Pharmaceutical (SHE: 300254) will purchase a stake of at least 80% in Hangzhou Baoling Group Co., Ltd. (see story). Baoling Group's main asset is a 75% ownership of Zhejiang Baoling Pharmaceutical Co., which produces healthcare and drug products for pregnant women. The purchase price was not disclosed.
BioClinica?, a clinical trial services company headquartered in the US, has formed a strategic partnership with TEDA International Cardiovascular Hospital (TICH) in Tianjin, China. The partnership will offer the company's cardiac safety monitoring services in Asia. BioClinica recently completed the first CFDA-requested Thorough QT (TQT) cardiac safety study in China for a domestic China company at the hospital.
Sichuan BoXin LaiTe Biotechnology and its major shareholder, Heracles International Investment Inc., have signed a memorandum of understanding to form a partnership with the Center for Blood Research (CBR) at the University of British Columbia. BoXin LaiTe and Heracles use their ability to validate the commercial and clinical of novel discoveries made at the CBR and accelerate their development for the China market.
Government and Regulatory
China's chief drug safety regulator, the CFDA, recently felt compelled to have a meeting with Johnson & Johnson (NYSE: JNJ) about product recalls. The problem was an article in a China newsletter alleging that J&J has recalled 51 products globally since 2005. But 48 of those products were not recalled in China, according to the publication. The apparent double standard required an explanation.
Disclosure: No positions
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Stanford Center for Sleep Sciences and Medicine: Stanford's Research Provides Hope for Patients With Narcolepsy
Julie Flygare and Dr. Emmanuel Mignot at the SLEEP 2013 meeting in Baltimore.
On a recent trip to San Francisco, I boarded a train headed south to Palo Alto to visit the Stanford Center for Narcolepsy. As the train whizzed through the Bay Area, I reflected on my long and unexpected journey to arrive at this point.
In 2005, I awoke one night to a burglar breaking into my apartment. I'd recently graduated from Brown University and moved into my first "grown up" apartment with a friend in Boston. On this evening, a man in a dark brown hoodie approached me with his arms stretched out toward my neck. I squirmed to get away, but couldn't move. My body was unresponsive, as if wearing a straitjacket.
A few minutes later, I could move again and sat up abruptly, my heart racing with adrenaline pumping. Where was the intruder now? The apartment was silent and all the windows and doors were securely locked. I went back to sleep, confused.
Later that year, I was laughing with a friend about a joke when my knees buckled slightly, as if someone had poked behind my knees. The weakness felt dramatic inside but passed quickly before I was sure what had happened.
This strange momentary weakness began happening every few weeks and started affecting my arms and neck as well. More emotions brought it on -- like annoyance, sexual pleasure, and surprise.
In the fall of 2006, I entered law school, excited for the academic challenges ahead. Before long, I was struggling more than I'd imagined, unable to stay awake in class and while studying at night. Where was my strong willpower?
One morning toward the end of my first year of law school, I awoke in my school's parking lot, unable to recall arriving there. I'd driven just 15 minutes in the morning after getting nine hours to sleep.
"Maybe I have a sleep problem," I said to myself for the first time.
By this time, burglars and other realistic night visitors invaded my sleep regularly. My body continued collapsing with emotions and had gotten worse. Now, I was falling to the ground for a minute or two, paralyzed and unable to speak or move, but remaining conscious and aware of my surroundings.
After multiple primary care doctors missed my diagnosis, I randomly mentioned my knee-buckling laughter to a sports medicine therapist who thought she'd heard of something like that called "cataplexy." At home, I Googled "cataplexy" and discovered it was defined as sudden muscle weakness often triggered by emotion. This described my knee-buckling laughter precisely.
I learned that cataplexy was a symptom of narcolepsy. Other symptoms included excessive daytime sleepiness, hypnagogic hallucinations, and sleep paralysis. Excessive daytime sleepiness offered a possible explanation for my difficulties staying awake. My realistic nighttime burglar experiences sounded a lot like hypnagogic hallucinations and sleep paralysis.
Soon thereafter, I visited a narcolepsy specialist and in September of 2007, at the age of 24, I was officially diagnosed with "narcolepsy with cataplexy," a neurological sleep disorder affecting one in 2,000 Americans and 3 million people worldwide, according to the Narcolepsy Network.
Adjusting to narcolepsy in law school wasn't easy. The treatments improved my symptoms but did not erase them. The medications' side effects left me nauseated and sick in other ways. A few months after the diagnosis, I reached an all-time low, realizing narcolepsy was a serious illness I would face every day of my life. There was no cure.
A half year later, I sat in the silent law school library reading a New York Times article about a researcher named Dr. Emmanuel Mignot, Director of Stanford University's Center for Narcolepsy. Dr. Mignot was unraveling the mysteries of narcolepsy and the possible autoimmune pathology.
The article described: "Dr. Mignot is optimistic about cracking the immune-system connection in narcolepsy soon. 'I don't care actually even if it's going to take a long time,' he said. 'I'm ready to cross deserts.'"
In the article, another doctor states that Dr. Mignot was ideally suited for this work, describing, "This is what is good about Mignot. He is relentless."
Goosebumps raised on my arms as I read this description of Dr. Mignot, a relentless researcher crossing deserts for narcolepsy. That day in the library, I vowed to do my part to help Dr. Mignot build a brighter future for narcolepsy. Although not a scientist, I was determined to make a contribution.
After graduating from law school, I moved to Washington, D.C. to write a memoir and advocate for narcolepsy research on Capitol Hill. I also ran the Boston Marathon in 2010 to raise funds for Dr. Mignot's research.
A few years later, while visiting San Francisco, I made the journey to Palo Alto to finally meet the man behind the magic, the Wizard of Narcolepsy.
Arriving at the Center for Narcolepsy's lab, I gave blood for research purposes and met various researchers exploring the mysteries of sleep and narcolepsy. The scientists patiently translated their work to me. Although some terms went over my head, coming together was joyful, a celebration of our mutual passion for the future of sleep and narcolepsy research.
Last but not least, I had the honor of meeting Dr. Mignot in person. He enthusiastically described his research priorities for the coming years.
"I have some crazy ideas too," he said with a smile and sparkle in his eye.
I couldn't help but chuckle. Dr. Mignot having "some crazy ideas" was great news.
As a person with narcolepsy, I face adversity daily. On hard days, I take solace in knowing that the Wizard of Narcolepsy and his fellow researchers at Stanford are working tirelessly and making progress. Their science is our hope.
Julie Flygare, JD is a leading narcolepsy spokesperson and author of Wide Awake and Dreaming: A Memoir of Narcolepsy. She writes the popular REM Runner blog, organizes the National Sleep Walk, and serves on NIH's Sleep Disorder Research Advisory Board. She is also a patient of the Stanford Center for Sleep Sciences and Medicine. This Center is the birthplace of sleep medicine and includes research, clinical, and educational programs that have advanced the field and improved patient care for decades. To learn more, visit us at: http://sleep.stanford.edu/.
Sources:
Narcolepsy Network. Accessed: June 17, 2013.
Narcolepsy Fact Sheet. National Institute of Neurological Disorders and Stroke. Accessed: June 17, 2013.
For more from the Stanford Center for Sleep Sciences and Medicine, click here.
For more on sleep, click here.
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